Dolasetron
生产企业：Sanofi aventis us llc
Dolasetron is an antinauseant and antiemetic used in chemotherapy and postoperatively.
Dolasetron is an antinauseant and antiemetic used in chemotherapy and postoperatively.
Dolasetron is a selective serotonin 5-HT receptor antagonist. In vivo, the drug is rapidly converted into its major active metabolite, hydrodolasetron, which seems to be largely responsible for the drug's pharmacological activity. The antiemetic activity of the drug is brought about through the inhibition of 5-HT receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.
For the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including initial and repeat courses of chemotherapy. Also used for the prevention of postoperative nausea and vomiting. This drug can be used intravenously for the treatment of postoperative nausea and vomiting.
