卡那霉素

概览

Kanamycin is an aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria.

作用机制

Aminoglycosides like kanamycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Kanamycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

适应症

For treatment of infections where one or more of the following are the known or suspected pathogens: E. coli, Proteus species (both indole-positive and indole-negative), E. aerogenes, K. pneumoniae, S. marcescens, and Acinetobacter species.

• Bacterial Infection caused by Acinetobacter species
• Bacterial Infection caused by E. coli
• Bacterial Infection caused by Enterobacter aerogenes
• Bacterial Infection caused by Klebsiella Pneumoniae
• Bacterial Infection caused by Proteus species
• Bacterial Infection caused by Serratia marcescens