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Turpentine is a medication used to treat minor aches and pains of muscles and joints.
Turpentine is a medication used to treat minor aches and pains of muscles and joints.
Binding of turpentine oil or inflammatory cytokines e.g. interleukin-1 (IL-1) activate signalling through the IL-1 Type 1 receptor (IL-1 R1). Initiation occurs by binding of Toll-interleukin 1 receptor adaptor protein (TIRAP) and Myeloid differentiation primary response gene 88 (mD88) which then dissociates and interacts with IRAK (Interleukin 1 receptor associated kinase) and the tumour necrosis factor receptor associated factor 6 (TRAF6). This activates the MAPK pathway leading to transcription of the nuclear factor κB transcription factor and production of inflammatory mediators.
Turpentine has been used experimentally in a bath for the treatment of disseminated sclerosis and sexual dysfunction. It also has been studied for its antibacterial activity and inhibition of osteoclast activity. Turpentine is utilized in experimental models of inflammation to induce a systemic inflammatory immune response in animals.
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