头孢噻肟 (Claforan)

概览

Cefotaxime is a third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections.

作用机制

The bactericidal activity of cefotaxime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefotaxime shows high affinity for penicillin-binding proteins in the cell wall including PBP Ib and PBP III.

适应症

Used to treat gonorrhoea, meningitis, and severe infections including infections of the kidney (pyelonephritis) and urinary system. Also used before an operation to prevent infection after surgery.

• Bone and Joint Infections caused by susceptible Bacterial Infections
• Central Nervous System Infections caused by susceptible Bacterial Infections
• Genitourinary tract infection caused by susceptible Bacterial Infections
• Gynaecological infection caused by susceptible bacteria
• Intraabdominal Infections caused by susceptible Bacterial Infections
• Lower Respiratory Tract Infection (LRTI) caused by susceptible bacteria
• Postoperative Wound Infection
• Septicemia caused by susceptible Bacterial Infections
• Skin and skin-structure infections caused by susceptible bacteria