西沙必利

概览

Cisapride is a medication used to treat heartburn associated with GERD.

作用机制

Cisapride acts through the stimulation of the serotonin 5-HT receptors which increases acetylcholine release in the enteric nervous system (specifically the myenteric plexus). This results in increased tone and amplitude of gastric (especially antral) contractions, relaxation of the pyloric sphincter and the duodenal bulb, and increased peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit.

适应症

For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.

• Gastrointestinal Disorder