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NC-1 (Necrocide-1) is a TRPM4 channel activator whose pharmacological effect is calcium-dependent: it activates TRPM4 at low intracellular calcium levels but loses efficacy at elevated calcium concentrations.
NC-1 (Necrocide-1) is a TRPM4 channel activator whose pharmacological effect is calcium-dependent: it activates TRPM4 at low intracellular calcium levels but loses efficacy at elevated calcium concentrations.
NC-1 (Necrocide-1) is a TRPM4 channel activator. Its activity is calcium-dependent: at low intracellular calcium levels, NC-1 activates TRPM4; at elevated calcium levels (as occur in stressed, injured, or diseased cells), NC-1 largely loses its activating effect on TRPM4.
