盐酸考尼伐坦 (Vaprisol)

概览

Conivaptan is an antidiuretic hormone inhibitor used to raise serum sodium levels.

作用机制

Conivaptan is a dual AVP antagonist with nanomolar affinity for human arginine vasopressin V and V receptors in vitro. This antagonism occurs in the renal collecting ducts, resulting in aquaresis, or excretion of free water.

适应症

For the treatment of euvolemic or hypervolemic hyponatremia (e.g. the syndrome of inappropriate secretion of antidiuretic hormone, or in the setting of hypothyroidism, adrenal insufficiency, pulmonary disorders, etc.) in hospitalized patients.

• Euvolemic Hyponatremia
• Hypervolemic Hyponatremia