利鲁唑 (Exservan, Rilutek, Tiglutik +1)

概览

Riluzole is a glutamate antagonist used to treat amyotrophic lateral sclerosis.

作用机制

The mode of action of riluzole is unknown. Its pharmacological properties include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release (activation of glutamate reuptake), 2) inactivation of voltage-dependent sodium channels, and 3) ability to interfere with intracellular events that follow transmitter binding at excitatory amino acid receptors.

适应症

For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)

• Amyotrophic Lateral Sclerosis (ALS)