厄他培南 (Invanz, Ertapenem SUN)

概览

Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe infections caused by susceptible bacteria.

作用机制

Ertapenem exhibits a bactericidal mode of action. It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs). In Escherichia coli, it has a strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preferential binding to PBPs 2 and 3. Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by interfering with the lengthening and strengthening of the peptidoglycan portion of the cell wall, thereby inhibiting cell wall synthesis.

适应症

Ertapenem is indicated to treat the following moderate to severe infections caused by susceptible bacteria in adult and pediatric patients (three months of age and older): Ertapenem is also used in adults for the prophylaxis of surgical site infection following elective colorectal surgery.

• Acute Gynecological Infection
• Severe Community-acquired Pneumonia (sCAP)
• Surgical Site Infections
• Acute, moderate Pelvic Infections caused by susceptible bacteria
• Acute, severe susceptible bacteria Pelvic Infections
• Moderate Community acquired pneumonia
• Moderate Complicated Intra-Abdominal Infections (cIAIs) caused by susceptible bacteria
• Moderate Diabetic Foot Infection
• Moderate Gynaecological infection caused by susceptible bacteria
• Moderate Postpartum Endomyometritis caused by susceptible bacteria
• Moderate Septic Abortion caused by susceptible bacteria
• Moderate complicated Urinary Tract Infection caused by susceptible bacteria