亚胺培南 (Primaxin, Recarbrio)

概览

Imipenem is a carbapenem antibiotic normally administered with cilastatin to treat a variety of infections.

作用机制

Imipenem acts as an antimicrobial through the inhibition of cell wall synthesis of various gram-positive and gram-negative bacteria. This inhibition of cell wall synthesis in gram-negative bateria is attained by binding to penicillin-binding proteins (PBPs). In E. coli and selected strains of P. aeruginosa, imipenem has shown to have the highest affinity to PBP-2, PBP-1a, and PBP-1b. This inhibition of PBPs prevents the bacterial cell from adding to the peptidoglycan polymer which forms the bacterial cell wall eventually leading to cell death.

适应症

Imipenem is indicated, in combination with cilastatin with or without relebactam, for the treatment of bacterial infections including respiratory, skin, bone, gynecologic, urinary tract, and intra-abdominal as well as septicemia and endocarditis.

• Bacterial Septicemia
• Bone and Joint Infections
• Complicated Intra-Abdominal Infections (cIAIs) caused by Gram-negative Bacteria
• Complicated Urinary Tract Infection
• Complicated Urinary Tract Infection caused by Gram-negative Bacteria
• Endocarditis caused by staphylococcus aureus
• Gynecological Infection
• Intraabdominal Infections
• Lower respiratory tract infection bacterial
• Nosocomial Pneumonia caused by Gram-negative Bacteria
• Pyelonephritis
• Skin and Subcutaneous Tissue Bacterial Infections