头孢孟多酯

概览

Cefamandole is a beta-lactam antibiotic used in the treatment of various infections caused by susceptible strains of bacteria, such as lower respiratory infections, urinary tract infections, skin infections, and bone and joint infections.

作用机制

Like all beta-lactam antibiotics, cefamandole binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefamandole interferes with an autolysin inhibitor.

适应症

For the treatment of serious infections caused by susceptible strains of microorganisms.

• Susceptible Bacterial Infections
• Severe Bacterial Infections
• Gram-Negative Bacterial Infections
• Sepsis