黏菌素 (Cortisporin-TC)

概览

Colistin is a polymyxin antibiotic used to treat bacterial infections caused by susceptible Gram negative bacteria.

作用机制

Colistin is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Colistin is polycationic and has both hydrophobic and lipophilic moieties. It interacts with the bacterial cytoplasmic membrane, changing its permeability. This effect is bactericidal. There is also evidence that polymyxins enter the cell and precipitate cytoplasmic components, primarily ribosomes.

适应症

For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.

• Ear infection bacterial
• External ear infection NOS