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NBDHEX is an extensively studied experimental compound that acts as a very efficient inhibitor of the glutathione S-transferase GSTP1-1. It was used as the basis for the rational development of activatable prodrugs, including the prodrug RK-251, which exhibits GSTP1-1 inhibition through the ROS-induced release of NBDHEX.
NBDHEX is an extensively studied experimental compound that acts as a very efficient inhibitor of the glutathione S-transferase GSTP1-1. It was used as the basis for the rational development of activatable prodrugs, including the prodrug RK-251, which exhibits GSTP1-1 inhibition through the ROS-induced release of NBDHEX.
NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. It induces apoptosis of tumor cells and possesses high antiproliferative activity against human cancer cell lines.