Sertindole

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Sertindole is an atypical antipsychotic indicated in the treatment of schizophrenia.

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概览

Sertindole is an atypical antipsychotic indicated in the treatment of schizophrenia.

作用机制

Sertindole is an antipsychotic drug with affinity for dopamine D2, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenoreceptors. Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low dopamine D2 occupancy level.

适应症

Used in the treatment of schizophrenia.

专利

每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。

Method for manufacture of sertindole
- US 2005101788 A1
  申请人: ZANON JACOPO优先权: 2005
  US
  2 件公开
- EP 1661887 A1
  申请人: LUNDBECK & CO AS H优先权: 2003
  EP
Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
US 6489341 B1申请人: SEPRACOR INC优先权: 2000
US
Clozapine and Cocaine Effects on Dopamine and Serotonin Release in Nucleus Accumbens During Psychostimulant Behavior and Withdrawal
US 2007270403 A1申请人: BRODERICK PATRICIA A优先权: 2004
US
Stable solid formulation of sertindole
- CN 101257906 A
  申请人: LUNDBECK & CO AS H优先权: 2005
  CN
- US 2007212412 A1
  申请人: LUNDBECK & CO AS H优先权: 2006
  US
USE OF SERTINDOLE FOR THE PREVENTIVE TREATMENT OF SUICIDAL BEHAVIOUR
US 2007281925 A1申请人: LUNDBECK & CO AS H优先权: 2007
US
Sertindole synthesis method
CN 101362749 A申请人: SHANGHAI INST PHARM INDUSTRY优先权: 2008
CN
Method for preparing sertindole
CN 101362748 B申请人: SHANGHAI INST PHARM INDUSTRY优先权: 2008
CN
ANTI-MANIC EFFECTIVE DOSES OF SERTINDOLE
US 2009270453 A1申请人: LUNDBECK & CO AS H优先权: 2009
US
Preparation method of 2-trifluoromethyl indole derivatives
CN 101987832 A申请人: UNIV WENZHOU优先权: 2009
CN
Novel preparation method of sertindole
CN 103214463 A申请人: BEIJING DVENTUREPHARM TECHNOLOGY DEV CO LTD优先权: 2013
CN

药物

Sertindole

概览

作用机制

适应症

相关疾病

专利

Method for manufacture of sertindole

Stable solid formulation of sertindole