螺旋霉素 (Rovamycin)

概览

Spiramycin is a macrolide antimicrobial agent used in the treatment of various bacterial infections.

作用机制

The mechanism of action of macrolides has been a matter of controversy for some time. Spiramycin, a 16-membered macrolide, inhibits translocation by binding to bacterial 50S ribosomal subunits with an apparent 1 : 1 stoichiometry. This antibiotic is a potent inhibitor of the binding to the ribosome of both donor and acceptor substrates. The primary mechanism of action is done by stimulation of dissociation of peptidyl-tRNA from ribosomes during translocation.I

适应症

Macrolide antibiotic for treatment of various infections.

• Bacterial Infections