Macimorelin (Macrilen, Ghryvelin (previously Macimorelin Aeterna Zentaris))

概览

Macimorelin is a medication used to treat adult growth hormone deficiency.

作用机制

Ghrelin is an endogenous ligand for the GH secretagogue receptor that is also called the ghrelin receptor (GHS-R1a). Upon activation of the receptor, ghrelin serves to increase growth hormone (GH) secretion. Macimorelin mimics the actions of ghrelin by stimulating GH release. As a synthetic agonist, it activates growth hormone secretagogue receptors present in the pituitary and hypothalamus.

适应症

Indicated for the diagnosis of adult growth hormone deficiency (AGHD) .

• Adult Onset Growth Hormone Deficiency