高血糖素 (Baqsimi, Glucagen, Gvoke +1)

概览

Glucagon is a form of recombinant glucagon used to treat hypoglycemia in diabetes mellitus and as a part of gastrointestinal imaging procedures.

作用机制

Glucagon binds to the glucagon receptor activating Gα and G. This activation activates adenylate cyclase, which increases intracellular cyclic AMP and activates protein kinase A. Activating G activates phospholipase C, increases production of inositol 1,4,5-triphosphate, and releases intracellular calcium. Protein kinase A phosphorylates glycogen phosphorylase kinase, which phosphorylates glycogen phosphorylase, which phosphorylates glycogen, causing its breakdown. Glucagon also relaxes smooth muscle of the stomach, duodenum, small bowel, and colon.

适应症

Glucagon is indicated as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.

• Severe Hypoglycemia