氟卡尼 (Tambocor)

概览

Flecainide is a class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT).

作用机制

Flecainide blocks fast inward sodium channels and slowly unbinds during diastole, prolonging the refractory period of the heart. This blockade also shortens the duration of action potentials through the Purkinjie fibers. Flecainide also prevents delayed rectifier potassium channels from opening, lengthening the action potential through ventricular and atrial muscle fibers. Finally, flecainide also blocks ryanodine receptor opening, reducing calcium release from sarcoplasmic reticulum, which reduces depolarization of cells.

适应症

In New Zealand and America, flecainide is indicated to prevent supraventricular arrhythmias and ventricular arrhythmias. In the United States, it is also indicated to prevent paroxysmal atrial fibrillation and flutter.

• Atrial Fibrillation
• Ventricular Tachycardia (VT)
• Severe Atrioventricular nodal reentrant tachycardia
• Severe Paroxysmal atrial fibrillation
• Severe Paroxysmal supraventricular tachycardia
• Severe Supraventricular Tachycardias
• Severe Sustained ventricular tachycardia
• Severe ventricular arrhythmias