萘甲唑啉 (Advanced Eye Relief Redness Instant Relief, Ak-con, Clear Eyes Complete +8)

概览

Naphazoline is a sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion.

作用机制

Naphazoline is a vasoconstrictor that functions by stimulating alpha adrenergic receptors in arterioles leading to decreased congestion at the site of administration. Naphazoline causes the release of norepinephrine in sympathetic nerves. Norepinephrine binds to alpha adrenergic receptors and causes vasoconstriction. Naphazoline is also a mild beta adrenergic receptor agonist, which can cause rebound vasodilation after the alpha adrenergic stimulation has ended. Naphazoline's release of norepinephrine also triggers a negative feedback loop which decreases production of norepinephrine, which can lead to rhinitis medicamentosa after long term use when naphazoline is stopped.

适应症

Naphazoline is indicated for use as OTC eyedrops for ocular vasoconstriction or as a nasal preparation for nasal congestion.

• Allergic Conjunctivitis (AC)
• Bacterial Conjunctivitis
• Blepharoconjunctivitis
• Conjunctivitis
• Dacryocystitis
• Dacryostenosis
• Dermatitis, Eczematous of the Eyelid
• Eye Pain
• Eye redness
• Foreign body sensation in eyes
• Iritis
• Lacrimation