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Oregovomab is a murine monoclonal antibody that attaches to the tumor-associated antigen CA125.
Oregovomab is a murine monoclonal antibody that attaches to the tumor-associated antigen CA125.
Oregovomab targets the circulating tumour-associated antigen CA 125, which is shed from the surface of human ovarian cancer cells; the antibodies induce broad cellular and humoral immune responses against CA 125 via complex formation. Unlike free CA 125, CA 125-oregovomab complexes can prime dendritic cells, leading to downstream activation of T cells.
Investigated for use/treatment in ovarian cancer.
