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Human olfactory mucosa-derived mesenchymal stem cells (OM-MSCs) reside in an accessible location of the nasal cavity and have properties of multipotency and high proliferation, which contributes to high potential for regenerative medicine. In humans, OM-MSCs are derived from the olfactory mucosa which is collected in vivo through rhinoscopy techniques and nasal forceps. OM-MSCs are also immunomodulatory and have potential for treating immunological diseases. Currently, OM-MSCs does not have wide application as there is not yet a standard and unambiguous protocol for OM-MSC collection, isolation, and therapeutic application.
Human olfactory mucosa-derived mesenchymal stem cells (OM-MSCs) reside in an accessible location of the nasal cavity and have properties of multipotency and high proliferation, which contributes to high potential for regenerative medicine. In humans, OM-MSCs are derived from the olfactory mucosa which is collected in vivo through rhinoscopy techniques and nasal forceps. OM-MSCs are also immunomodulatory and have potential for treating immunological diseases. Currently, OM-MSCs does not have wide application as there is not yet a standard and unambiguous protocol for OM-MSC collection, isolation, and therapeutic application.
OM-MSCs’ immunomodulating activities are partially related to CD4+ T-lymphocytes, B-lymphocytes, macrophages, and dendritic cells. OM-MSCs were also found to suppress cytotoxic functions of CD8 + cytotoxic lymphocytes and natural killer cells. Potential applications include in the field of experimental neurology to employ it for treatment of different types of lesions and neurodegenerative diseases of the central nervous system, hippocampal lesions, regeneration of peripheral nerves and cranial nerves, and for spinal cord trauma. There are also potentials for immunosuppression for autoimmune diseases and regenerative promotion for myocardial tissue after infarction and also against ischemic tissues.
