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Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.
Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.
Piboserod appears to act as a specific antagonist of one of the receptors for 5-hydroxytryptamine, the 5-HT4 receptor. The 5-HT4 receptor antagonists are thought to antagonize both the ability of serotonin to sensitize the peristaltic reflex and 5-HT-induced defecation, at least in animal studies. As 5-HT4 receptors are present in human atrial cells and when stimulated may cause atrial arrhythmias, piboserod was under investigation in clinical trials for atrial fibrillation.
For the treatment of atrial fibrillation and irritable bowel syndrome (IBS).
