Perhexiline
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Perhexiline is a coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Perhexiline is a coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Perhexiline binds to the mitochondrial enzyme carnitine palmitoyltransferase (CPT)-1 and CPT-2. It acts by shifting myocardial substrate utilisation from long chain fatty acids to carbohydrates through inhibition of CPT-1 and, to a lesser extent, CPT-2, resulting in increased glucose and lactate utilization. This results in increased ATP production for the same O2 consumption as before and consequently increases myocardial efficiency.
For the management of severe angina pectoris.
