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ATL146e is an anti-inflammatory compounds which is an agonist of A2A adenosine receptors.
ATL146e is an anti-inflammatory compounds which is an agonist of A2A adenosine receptors.
ATL146e can inhibit neutrophil, macrophage and T cell activation and thereby reduce inflammation caused autoimmune responses. It also inhibits TNF-α and IL-1/3 production, neutrophil accumulation in gastric injury induced by NSAIDS (such as aspirin) without affecting mucosal prostaglandin E2 (PGE2) concentration. The effects of adenosine A2A agonists can be enhanced by type IV phosphodiesterase inhibitors, such as rolipram.
Investigated for use/treatment in inflammatory disorders (unspecified).
