氨苯砜 (Aczone)

概览

Dapsone is a sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis.

作用机制

Dapsone acts against bacteria and protozoa in the same way as sulphonamides, that is by inhibiting the synthesis of dihydrofolic acid through competition with para-amino-benzoate for the active site of dihydropteroate synthetase. The anti-inflammatory action of the drug is unrelated to its antibacterial action and is still not fully understood.

适应症

For the treatment and management of leprosy and dermatitis herpetiformis.

• Acne Vulgaris
• Bullous Systemic Lupus Erythematosus
• Bullous dermatitis herpetiformis
• Hansen's Disease
• Pemphigus Vulgaris (PV)
• Relapsing Polychondritis
• Mild Pneumocystis pneumonia
• Mild Toxoplasma gondii encephalitis
• Moderate Pneumocystis pneumonia
• Moderate Toxoplasma gondii encephalitis
• Refractory Idiopathic thrombocytopenic purpura