Pheniramine
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Pheniramine is an antihistamine used to treat allergic rhinitis and pruritus.
Pheniramine is an antihistamine used to treat allergic rhinitis and pruritus.
Pheniramine competes with histamine for the histamine H1 receptor, acting as an inverse agonist once bound. The reduction in H1 receptor activity is responsible for reduced itching as well as reduced vasodilation and capillary leakage leading to less redness and edema. This can be seen in the suppression of the histamine-induced wheal (swelling) and flare (vasodilation) response. Inverse agonism of the H1 receptor in the CNS is also responsible for the sedation produced by first-generation antihistamines like pheniramine. The binding of pheniramine to H4 receptors, and subsequent inverse agonism, may also contribute to reduced itching by antagonizing inflammation.
常用于过敏性疾病和感冒等。
共 17 项相关疾病
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