Ixazomib
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Ixazomib is a monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already.
Ixazomib is a monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already.
Ixazomib is an N-capped dipeptidyl leucine boronic acid which reversibly inhibits the CT-L proteolytic (β5) site of the 20S proteasome. At higher concentrations, ixazomib also seems to inhibit the proteolytic β1 and β2 subunits and to induce accumulation of ubiquitinated proteins.
Ixazomib is indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy.
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