非诺多泮 (Corlopam)

概览

Fenoldopam is a dopamine D1 receptor agonist used for the short term management of hypertension.

作用机制

Fenoldopam is a rapid-acting vasodilator. It is an agonist for D-like dopamine receptors and binds with moderate affinity to α-adrenoceptors. It has no significant affinity for D-like receptors, α and β-adrenoceptors, 5 and 5 receptors, or muscarinic receptors. Fenoldopam is a racemic mixture with the R-isomer responsible for the biological activity. The R-isomer has approximately 250-fold higher affinity for D-like receptors than does the S-isomer. In non-clinical studies, fenoldopam had no agonist effect on presynaptic D-like dopamine receptors, or α or β -adrenoceptors, nor did it affect angiotensin-converting enzyme activity. Fenoldopam may increase norepinephrine plasma concentration.

适应症

用于极严重高血压或住院不能口服药物的高血压患者初1～2天的对症处理。

• Malignant Hypertension
• Severe Hypertension