Clorazepic acid

概览

Clorazepic acid is a benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal.

作用机制

Clorazepate is a benzodiazepine with depressant effects on the central nervous system. Benzodiazepines are able to enhance the binding of gamma-aminobutyric acid (GABA) to the GABA type A (GABA-A) receptor by binding to a region in the extracellular domain found at the interface between the alpha (α) and gamma (γ) subunits of the GABA-A receptor. The interaction of GABA and the GABA-A receptor promotes channel opening, leading to an increased chloride influx. Consequently, the use of benzodiazepines, such as clorazepate, leads to neuronal hyperpolarization.

适应症

Clorazepate is indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety. It is also used as adjunctive therapy in the management of partial seizures and for the symptomatic relief of acute alcohol withdrawal.

• Acute Alcohol Withdrawal
• Anxiety Acute
• Generalized Anxiety Disorder
• Partial-Onset Seizures