Verzenios is a cancer medicine used to treat women with breast cancer that is advanced or has spread to other parts of the body (metastatic). It is also used to treat men and women with early breast cancer after surgery where the cancer has spread to the lymph nodes (node-positive) and display other features indicating a higher risk for the cancer to come back. Verzenios can only be used when the cancer cells have certain types of receptor (called hormone receptors) on their surface (HR-positive) and do not produce abnormally large quantities of another receptor called HER2 (HER2-negative). It is used together with a hormonal medicine, such as tamoxifen, an aromatase inhibitor or fulvestrant. In women who have not yet reached menopause, a medicine called a luteinising hormone-releasing hormone agonist should also be given. Verzenios contains the active substance abemaciclib.
Therapeutic Indication
### Therapeutic indication Early Breast Cancer Verzenios in combination with endocrine therapy is indicated for the adjuvant treatment of adult patients with hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) negative, node positive early breast cancer at high risk of recurrence (see section 5.1). In pre or perimenopausal women, aromatase inhibitor endocrine therapy should be combined with a luteinising hormone-releasing hormone (LHRH) agonist. Advanced or Metastatic Breast Cancer Verzenios is indicated for the treatment of women with hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) negative locally advanced or metastatic breast cancer in combination with an aromatase inhibitor or fulvestrant as initial endocrine-based therapy, or in women who have received prior endocrine therapy. In pre- or perimenopausal women, the endocrine therapy should be combined with a LHRH agonist.
Therapeutic Area (MeSH)
ATC Code
L01EF03
ATC Item
abemaciclib
Pharmacotherapeutic Group
Antineoplastic agents
Active Substance (Summary)
INN / Common Names
| Substance | CAS | Monograph |
|---|---|---|
| abemaciclib | N/A | 阿贝西利 |
EMA Name
Verzenios
Medicine Name
Verzenios
Aliases
N/A
