Tecartus is a cancer medicine used to treat: - adults with mantle cell lymphoma (a cancer of B cells, a type of white blood cell) when the cancer has come back after two or more previous treatments, including a type of cancer medicine called a Bruton’s tyrosine kinase (BTK) inhibitor; - adults 26 years of age and older with acute lymphoblastic leukaemia (another cancer of B cells) when the cancer has come back or did not respond to previous treatments. These type of B-cell cancers are rare, and Tecartus was designated an ‘ [orphan medicine’](/en/medicines/human/orphan-designations/eu-3-19-2220) (a medicine used in rare diseases) for mantle cell lymphoma on [13 November 2019](/en/medicines/human/orphan-designations/eu-3-19-2220) and for acute lymphoblastic leukaemia on [19 October 2020](/en/medicines/human/orphan-designations/eu-3-20-2344). Tecartus contains the active substance brexucabtagene autoleucel, which consists of genetically modified white blood cells.
Therapeutic Indication
### Therapeutic indication **Mantle cell lymphoma** Tecartus is indicated for the treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL) after two or more lines of systemic therapy including a Bruton’s tyrosine kinase (BTK) inhibitor. **Acute lymphoblastic leukaemia** Tecartus is indicated for the treatment of adult patients 26 years of age and above with relapsed or refractory B-cell precursor acute lymphoblastic leukaemia (ALL).
Therapeutic Area (MeSH)
ATC Code
L01X
ATC Item
其它抗肿瘤药物
Pharmacotherapeutic Group
Antineoplastic agents
Active Substance (Summary)
INN / Common Names
| Substance | CAS | Monograph |
|---|---|---|
| autologous peripheral blood T cells CD4 and CD8 selected and CD3 and CD28 activated transduced with retroviral vector expressing anti-CD19 CD28/CD3-zeta chimeric antigen receptor and cultured (brexucabtagene autoleucel) | N/A | autologous peripheral blood t cells cd 4 and cd 8 selected and cd 3 and cd 28 activated transduced with retroviral vector expressing anti-cd 19 cd 28/cd 3-zeta chimeric antigen receptor and cultured (brexucabtagene autoleucel) |
EMA Name
Tecartus
Medicine Name
Tecartus
Aliases
N/A