- Approval Id
- a8a7cd151f99cff1
- Drug Name
- SODIUM BICARBONATE INTRAVENOUS INFUSION 8.4% W/V
- Product Name
- SODIUM BICARBONATE INTRAVENOUS INFUSION 8.4% W/V
- Approval Number
- SIN09226P
- Approval Date
- 1997-02-20
- Registrant
- B. BRAUN SINGAPORE PTE LTD
- Licence Holder
- B. BRAUN SINGAPORE PTE LTD
- Drug Type
- Therapeutic
- Forensic Classification
- GENERAL SALE LIST
- Dosage Form
- INJECTION
- Dosage
- <p><strong>Dosage</strong><br>
The quantity of Sodium Bicarbonate Intravenous Infusion BP to be infused is determined by the blood gas values and is calculated according to the following formulae:<br>
mL of 8.4% w/v Sodium Bicarbonate Intravenous Infusion BP<br>
= negative base excess x kg b.w. x 0.3<br>
(The factor 0.3 corresponds to the proportion of the extracellular fluid in relation to total body fluid).<br>
The maximum daily dose is determined according to the correction requirements.</p>
<p>Correction of metabolic acidosis should not be affected too rapidly. It is advisable to start administering only half of the calculated dose and adjust further doses according to the actual results of blood gas analysis.<br>
Blind buffer therapy is not advisable. It should only be performed in life-threatening situations.</p>
<p><em>Flow rate</em><br>
Up to 1.5 mmol of sodium bicarbonate per kg body weight per hour, corresponding to 1.5 ml of 8.4% w/v Sodium Bicarbonate Intravenous Infusion BP/kg bw/h.</p>
<p><em>Route of administration</em><br>
Strictly intravenously! 8.4% w/v Sodium Bicarbonate<br>
Intravenous Infusion BP has an osmolarity of about 2000 mOsm/l and, when infused undiluted, it should be administered via central venous catheter, preferably inserted into the vena cava.</p>
- Route Of Administration
- INTRAVENOUS
- Indication Info
- <p><strong>Indications</strong><br>
Correction of metabolic acidosis;<br>
Urine alkalinisation in the case of intoxication with weak organic acids, e.g. barbiturates or acetylsalicylic acid;<br>
Urine alkalinisation in order to improve the solubility of drug substances which are poorly soluble in neutral or acid medium, e.g. methotrexate, sulphonamides;<br>
Urine alkalinisation in the case of haemolysis.</p>
- Contraindications
- <p><strong>Contraindications</strong><br>
Respiratory and metabolic alkalosis,<br>
Hypernatremia,<br>
Hypokalemia.</p>
- Atc Code
- B05XA02
- Atc Item Name
- sodium bicarbonate
- Pharma Manufacturer Name
- B. Braun Singapore Pte Ltd.
- Company Detail Path
- /organization/b-braun-singapore-pte-ltd
