多非利特 (Tikosyn)

概览

Dofetilide is a class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter.

作用机制

The mechanism of action of Dofetilide is a blockade of the cardiac ion channel carrying the rapid component of the delayed rectifier potassium current, IKr. This inhibition of potassium channels results in a prolongation of action potential duration and the effective refractory period of accessory pathways (both anterograde and retrograde conduction in the accessory pathway).

适应症

用于心房扑动、心房颤动、室上性心动过速。

• Normal Sinus Rhythm
• Symptomatic Atrial flutter
• Symptomatic, recurrent Atrial Fibrillation