沃替西汀 (Brintellix, Trintellix)

概览

Vortioxetine is a serotonin modulating antidepressant indicated for the treatment of major depressive disorder (MDD).

作用机制

Vortioxetine is classified as a serotonin modulator and simulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake of serotonin. More specifically, vortioxetine acts via the following biological mechanisms: as a serotonin reuptake inhibitor (SRI) through inhibition of the serotonin transporter, while also acting as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors.

适应症

用于治疗重度抑郁症成人患者。

• Major Depressive Disorder (MDD)