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AdPEDF is under development for the treatment of wet age-related macular degeneration (AMD). It has been shown to rapidly elevate the intraocular AdPEDF protein levels in the eye, inhibit abnormal blood vessel growth, and cause abnormal blood vessels to regress while protecting the eye’s photoreceptors.
AdPEDF is under development for the treatment of wet age-related macular degeneration (AMD). It has been shown to rapidly elevate the intraocular AdPEDF protein levels in the eye, inhibit abnormal blood vessel growth, and cause abnormal blood vessels to regress while protecting the eye’s photoreceptors.
AdPEDF is an adenoviral-based vector containing the gene for human pigment epithelium-derived factor (PEDF), a protein found in the eye that normally regulates blood vessel growth in the eye and protects the cells of the retina from damage. AdPEDF is designed to deliver sustained levels of the human Pigment Epithelium-Derived Factor (PEDF) protein in the eye. PEDF is the eye’s key natural regulator of normal blood vessel growth and neuronal function and has been demonstrated to have dual potent antiangiogenic and neuroprotective properties.
Investigated for use/treatment in macular degeneration.
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