Estradiol benzoate
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Estradiol benzoate is an estrogen indicated in combination with progesterone for the treatment of irregular menstruation.
Estradiol benzoate is an estrogen indicated in combination with progesterone for the treatment of irregular menstruation.
Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.
Estradiol benzoate is not currently available in any FDA or Health Canada approved products.
