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αAβ–Gas6 is a chimeric fusion protein being investigated for Alzheimer's disease.
αAβ–Gas6 is a chimeric fusion protein being investigated for Alzheimer's disease.
TAM (TYRO3, AXL, and MERTK) receptors are receptor tyrosine kinases expressed ubiquitously, including microglia and astrocytes of the nervous system. They play a critical role in homeostatic processes such as phagocytosis of apoptotic cells and membranous organelles, and regulation of inflammatory responses and inflammation. αAβ-Gas6 targets TAM receptors by binding to growth arrest-specific 6 (Gas6), a ligand for TAM receptors. By activating the TAM receptor signalling pathway, αAβ-Gas6 promotes TAM receptor-dependent phagocytosis to selectively eliminate Aβ plaques without affecting NF-kB-mediated inflammatory responses or reactive gliosis.
每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。
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