氯苯唑酸葡胺 (Vyndamax, Vyndaqel)

概览

Tafamidis is a medication used to treat transthyretin-mediated amyloidosis.

作用机制

Genetic mutations or natural misfolding of transthyretin destabalizes transthyretin tetramers, leading to their dissociation and aggregation in tissues, and disrupting the normal function of these tissues. Tafamidis binds to transthyretin tetramers at the thyroxin binding sites, stabilizing the tetramer, reducing the availability of monomers for amyloidogenesis.

适应症

Tafamidis is indicated to treat cardiomyopathy of wild type or hereditary transthyretin-mediated amyloidosis in adults.

• Cardiomyopathy