布罗索尤单抗 (Crysvita)

概览

Burosumab is a fibroblast growth factor 23 blocking antibody used to treat X-linked hypophosphatemia.

作用机制

Burosumab is a recombinant human monoclonal antibody (IgG1) that both binds to and inhibits the actions of fibroblast growth factor 23 (FGF23). By inhibiting this growth factor, burosumab increases the tubular reabsorption of phosphate from the kidney and thus increases serum concentration of 1, 25 dihydroxy-Vitamin D . This form of vitamin D enhances intestinal absorption of phosphate and calcium, supporting bone mineralization .

适应症

This drug is indicated for the treatment of X-linked hypophosphatemia with radiological evidence of bone disease in children of 1 year of age and older and adolescents with growing skeletons .

• Hypophosphatemia
• X-Linked Hypophosphatemia