雌莫司汀 (Emcyt)

概览

Estramustine is an antineoplastic agent used for the management of metastatic and/or progressive prostate cancer in palliative setting.

作用机制

Estramustine is a derivative of estradiol with a nitrogen mustard moiety. This gives it alkylating properties. In vivo, the nitrogen mustard component is active and can alklyate DNA and other cellular components (such as tubulin components) of rapidly dividing cells. This causes DNA strandbreaks or misscoding events. This leads to apoptosis and cell death. Also, due to the drugs estrogen component, it can bind more selectively to active estrogen receptors.

适应症

For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate

• Metastatic Prostate Cancer