毒扁豆碱

概览

Physostigmine is a cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity.

作用机制

Physostigmine inhibits acetylcholinesterase, the enzyme responsible for the breakdown of used acetylcholine. By interfering with the metabolism of acetylcholine, physostigmine indirectly stimulates both nicotinic and muscarinic receptors due to the consequential increase in available acetylcholine at the synapse.

适应症

For the treatment of glaucoma, and in the treatment of severe anticholinergic toxicity.

• Anticholinergic Syndrome