炔诺孕酮 (Cryselle 28, Elinest 28 Day, Lo/ovral 28 Day +2)

概览

Norgestrel is a progestin used in combination with ethinyl estradiol for oral contraception and prevention of pregnancy in women.

作用机制

Norgestrel (and more specifically the active stereoisomer levonorgestrel) binds to the progesterone and estrogen receptors within the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like levonorgestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. Loss of the LH surge inhibits ovulation and thereby prevents pregnancy.

适应症

Norgestrel in combination with ethinyl estradiol is indicated for the prevention of pregnancy in women who elect to use this product as a method of contraception.

• Abnormal Uterine Bleeding
• Endometriosis
• Hypermenorrhea
• Menstrual Distress (Dysmenorrhea)
• Polycystic Ovarian Syndrome (PCOS)