鹅去氧胆酸 (Chenodal, Chenodeoxycholic acid Leadiant (previously known as Chenodeoxycholic acid sigma-tau))

概览

Chenodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis.

作用机制

Chenodiol suppresses hepatic synthesis of both cholesterol and cholic acid, gradually replacing the latter and its metabolite, deoxycholic acid in an expanded bile acid pool. These actions contribute to biliary cholesterol desaturation and gradual dissolution of radiolucent cholesterol gallstones in the presence of a gall-bladder visualized by oral cholecystography. Bile acids may also bind the the bile acid receptor (FXR) which regulates the synthesis and transport of bile acids.

适应症

Chenodiol is indicated for patients with radiolucent stones in well-opacifying gallbladders, in whom selective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease or age. Chenodiol will not dissolve calcified (radiopaque) or radiolucent bile pigment stones.

• Radiolucent Cholesterol gallstones