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An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals. [PubChem]
An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals. [PubChem]
Methylglyoxal (MG) directly activates GABA-A receptors on neurons, producing a rapid inhibitory effect. This represents a previously unknown mechanism linking neuronal inhibitory tone to metabolic activity. MG is an endogenous byproduct of glycolysis that is normally metabolized by glyoxylase 1 (Glo1); inhibiting Glo1 raises MG levels, which in turn enhances GABA-A receptor-mediated inhibition.
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