伊达比星 (Idamycin)

概览

Idarubicin is an anthracycline antineoplastic agent used to treat acute myeloid leukemia (AML) in adults.

作用机制

Idarubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Idarubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

适应症

For the treatment of acute myeloid leukemia (AML) in adults. This includes French-American-British (FAB) classifications M1 through M7.

• Acute Myeloid Leukemia