Gramicidin D (Sofracort, Soframycin, Triple Antibiotic +1)

概览

Gramicidin D is a bactericidal antibiotic used in the treatment of dermatological and ophthalmic infections.

作用机制

Gramicidin D binds to and inserts itself into bacterial membranes (with a strong preference to gram-positive cell membranes). This results in membrane disruption and permeabilization (it acts as a channel). This leads to (i) loss of intracellular solutes (e.g., K+ and amino acids); (ii) dissipation of the transmembrane potential; (iii) inhibition of respiration; (iv) a reduction in ATP pools; and (v) inhibition of DNA, RNA, and protein synthesis, which leads to cell death.

适应症

For treatment of skin lesions, surface wounds and eye infections.

• Allergic Conjunctivitis (AC)
• Allergic Skin Reaction
• Blepharoconjunctivitis
• Conjunctivitis
• Conjunctivitis infective
• Episcleritis
• External ear inflammation
• Eye and eyelid infections
• Inflammatory Skin Disease
• Iridocyclitis
• Keratitis
• Ocular Inflammation