替奈普酶 (Metalyse, Tnkase, Tenecteplase Boehringer Ingelheim Pharma GmbH Co. KG)

概览

Tenecteplase is a modified form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli.

作用机制

Tenecteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.

适应症

用于溶栓治疗。

• Cardiovascular Mortality