塞奈吉明 (Oxervate)

概览

Cenegermin is a recombinant human nerve growth factor used to treat neurotrophic keratitis.

作用机制

Cenegermin is a recombinant form of human nerve growth factor . Neurotrophic keratitis is a degenerative disease resulting from a loss of corneal sensation . The loss of corneal sensation impairs corneal health causing progressive damage to the top layer of the cornea, including corneal thinning, ulceration, and perforation in severe cases . Nerve growth factor is subsequently an endogenous protein involved in the differentiation and maintenance of neurons, which acts through specific high-affinity (i.e., TrkA) and low-affinity (i.e. p75NTR) nerve growth factor receptors . Nerve growth factor receptors are expressed in the anterior segment of the eye (cornea, conjunctiva, iris, ciliary body, and lens), by the lacrimal gland, and by posterior segment intraocular tissues . The treatment with cenegermin, administered as eye drops, is intended to allow restoration of corneal integrity .

适应症

Cenegermin is indicated for the treatment of moderate (persistent epithelial defect) or severe (corneal ulcer) neurotrophic keratitis in adults .

• Neurotrophic Keratopathy