美卡拉明 (Inversine, Vecamyl)

概览

Mecamylamine is a nicotine antagonist used to treat moderate to severe essential hypertension and uncomplicated malignant hypertension.

作用机制

Mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural.

适应症

For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension

• Severe Hypertension
• Moderate Hypertension
• Uncomplicated Malignant hypertension