普萘洛尔 (Hemangeol, Hemangiol, Inderal +1)

概览

Propranolol is a non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma.

作用机制

Propranolol is a nonselective β-adrenergic receptor antagonist. Blocking of these receptors leads to vasoconstriction, inhibition of angiogenic factors like vascular endothelial growth factor (VEGF) and basic growth factor of fibroblasts (bFGF), induction of apoptosis of endothelial cells, as well as down regulation of the renin-angiotensin-aldosterone system.

适应症

Propranolol is indicated to treat hypertension. Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.

• Akathisia caused by antipsychotic use
• Angina Pectoris
• Atrial Fibrillation
• Cardiovascular Mortality
• Essential Tremor
• Gastroesophageal variceal hemorrhage prophylaxis
• Hemangiomas
• Hypertension
• Migraine
• Myocardial Infarction
• Obstructive Hypertrophic Cardiomyopathy
• Performance Anxiety